The effectiveness of a home based strengthening exercise programme combined with oral nutrition in improving muscle mass, strength and function in people aged 65 years and over

Not Applicable

Completed

• Conditions: Sarcopenia; Low bone mineral content; Low muscle mass; Low muscle strength; Inflammation; Diet and Nutrition - Other diet and nutrition disorders; Musculoskeletal - Other muscular and skeletal disorders; Musculoskeletal - Osteoporosis; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12618001916235
• Lead Sponsor: The University of Newcastle

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-11-26
• Study Completion: 2021-04-27
• Last Update Posted: 10 April 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 95

Inclusion Criteria

Males and females; age 65 years or more

Exclusion Criteria

BMI >40kg/m2
Usual dietary protein intake >1.0 g/kg BW/day
Participation in resistance exercise (>1 wk), moderate-intensity exercise greater than or equal to 150 min/wk and/or vigorous exercise greater than or equal to 60 min/wk over the past 3 months
Unwilling or unable to undertake resistance training exercise programme (eg severe osteoarthritis)
Unwilling or unable to consume the study drink or cow’s milk
Allergies or intolerance to soy (self-reported)
Regular (>3 times per week) protein supplement (eg. Sustagen) use
Medical conditions requiring a specialised dietary plan (eg insulin dependent diabetes)
Current smokers (smoked within past 6 months)
Abnormal blood chemistry panel at screening
Chronic or excessive alcohol consumption (as evidenced by abnormal liver function tests)
Significant weight loss (>5% BW) in the past 6 months
Current use of systemic anti-inflammatory or immunosuppressant medications (eg corticosteroids)
Current use of medication that may affect muscle metabolism (eg corticosteroids or thyroxine)
Unstable cardiac condition
Diagnosis of renal (eGFR<30) or hepatic failure; terminal illness, human immunodeficiency virus (HIV) or cognitive impairment (Mini mental state exam score <24).
Any other medical condition which may interfere with the participant’s ability to participate in the intervention. For example a diagnosis of osteoporosis and a history of recent multiple non-trauma fractures.

Study & Design

• Study Type: Interventional
• Study Design: Not specified