A Study to Assess Thymic Function Using PET/CT and MRI
- Conditions
- CD34 Selected Peripheral Blood Stem Cell Graft
- Registration Number
- NCT02909075
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Brief Summary
The purpose of this study is to see if a positron emission tomography/computed tomography (PET/CT) scan and a magnetic resonance imaging (MRI) of the chest can assess changes in the thymus size and function. The researchers would like to monitor the thymus with a PET/CT scan and a MRI before and after the participants transplantation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 3
- Patient's age is ≥18 or ≤65 years old.
- Patients must have a plan to receive a CD34-selected peripheral blood stem cell graft.
- Patient is not able to undergo MR imaging due to any contraindication to MRI based on departmental MR questionnaire (e.g. past gadolinium allergies, failure of metallic screening, claustrophobia, inability to lay flat for duration of the study, inability to hold breath, etc.)
- Pregnant or breastfeeding.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change in thymic size 1 year A clinically meaningful change is defined as increase in thymic size (\> 0.2cm increase in uni-dimensional diameter), functional volume (\>10%) or uptake (≥25%). We will report proportion of patients with each component of clinically meaningful change, as well as the proportion with at least one component, along 95% exact confidence intervals.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (3)
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Memorial Sloan-Kettering Cancer Center at Commack
🇺🇸Commack, New York, United States
Memorial Sloan Kettering Westchester
🇺🇸Harrison, New York, United States
Memorial Sloan Kettering Cancer Center🇺🇸New York, New York, United States