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临床试验/CTRI/2023/06/053513
CTRI/2023/06/053513尚未招募不适用

Assessment of Clinical Characteristics, Electrolyte Imbalance & Outcome in Patients Hospitalized in Intensive Care Unit with Severe Covid-19 Disease - A Single Centered Retrospective Observational Study

The Dean, GMCHA1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2023年10月6日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
200
试验地点
1
主要终点
Correlation between the level of the electrolyte disturbances and the morbidity and mortality in patients hospitalized in intensive care unit with severe Covid -19 disease

研究概览

简要总结

Electrolyte disturbances have important implications not only for patient management but also for identifying & better understanding of potential pathophysiologic mechanisms underlying COVID-19.  A single-center, retrospective, observational study will be carried out to find any correlation between the level of the electrolyte disturbances and the morbidity and mortality, acid base disturbances on admission & outcome, prognostic factors associated with disease progression & mortality risk in patients hospitalized in intensive care unit with severe Covid -19 disease

This study will follow the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. Male & female patients 18-65 years old who were confirmed by the real-time PCR/Rapid antigen test on the respiratory tract samples as positive of SARS-CoV-2.

hospitalized in intensive care unit from 1 July 2020 until 31 October 2020 died and recovered with Covid-19 disease will be collected retrospectively & analyzed.

Data on age, sex, laboratory values during admission (hemoglobin concentration, lymphocyte count, platelet count, arterial blood gas analysis, markers of inflammation, serum and urine creatinine, urea, serum and serum and urine electrolyte), comorbidities, sign and symptoms at presentation, vital signs, administered treatment (diuretics, electrolyte supplement), as well as the admission in ICU.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • Male & female patients confirmed by the real-time PCR/Rapid antigen test on the respiratory tract samples as positive of SARS-CoV-2
  • Patients hospitalized in dedicated Covid-19 intensive care unit.

排除标准

  • Patients who had other causes of electrolyte disturbance
  • Chronic organ dysfunction (e.g., hepatic or renal dysfunction),
  • Terminal cancer immunodeficiency
  • Patients with a history of long-term use of hormones & diuretics.

结局指标

主要结局

Correlation between the level of the electrolyte disturbances and the morbidity and mortality in patients hospitalized in intensive care unit with severe Covid -19 disease

时间窗: 1. Discharge from intensive care unit | 2. Death

次要结局

  • -Acid base disturbances on admission & outcome(Prognostic factors associated with disease progression & mortality risk)

研究者

发起方
The Dean, GMCHA
申办方类型
Government medical college

研究点 (1)

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