NCT03025425终止不适用
Palliation of Dyspnea With Mouth Piece Ventilation in Acute Exacerbation of COPD Without Respiratory Insufficiency
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in dyspnea after initial period of using MPV
研究概览
简要总结
An uncontrolled feasibility study on using mouth piece ventilation in palliation of dyspnea in subjects with acute exacerbation of COPD without acute hypercapnic respiratory failure. Subjects are recruited from the local respiratory ward. The main outcomes are the compliance of the subjects with the treatment and alleviation of dyspnea during the treatment period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •a previous diagnosis of COPD
- •hospitalized due to acute exacerbation of COPD
- •at least moderate dyspnea (NRS = Numeric Rating Scale ≥ 4)
- •no acute hypoventilation (pH ≥ 7.35 and PCO2 ≤ 6.0 kPa)
- •able to understand the study and to give informed consent
排除标准
- •unable to participate and use MPV due to e.g. delirium or lack of co-operation
- •acute hypoventilation (pH < 7.35 or PCO2 > 6.0 kPa)
- •acute need for ventilatory support
- •the cause of the dyspnea can be successfully treated
- •unable to give informed consent
- •a previous chronic hypoxemic or hypercapnic respiratory insufficiency that has been treated on a long-term basis also at home
结局指标
主要结局
Change in dyspnea after initial period of using MPV
时间窗: 5-60 min
Change in dyspnea after initial period of using MPV
次要结局
- Proportion of subjects having side-effects or not being compliant with MPV(24 hours)
- Change in dyspnea after 24 hours of using MPV(24 hours)
- Proportion of subjects gaining from MPV(24 hours)
- Proportion of subjects willing to continue on MPV after the intervention(24 hours)
研究者
Lauri Lehtimäki
Associate Professor
Tampere University Hospital
研究点 (2)
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