Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study

Not Applicable

• Conditions: Ventricular Fibrillation; Ventricular Tachycardia

• Registration Number: NCT00176176
• Lead Sponsor: Heidelberg University

Brief Summary

In this study, changes in electroencephalogram (EEG) and the hemodynamic state during ventricular fibrillation or induced ventricular tachycardia are investigated.

Detailed Description

Patients with a high risk of malignant tachyarrhythmia are routinely investigated by programmed electrophysiological study (EPS). To investigate the hemodynamic effects of ventricular arrhythmia to cerebral circulation an EEG and transcranial ultrasound are conducted simultaneously during the EPS. Before and after the EPS a neuropsychological test and an investigation of a specific blood sample (Neuron Specific Enolase, NSE) is done.

Study Timeline

• Status Verified: 2004-11
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-15
• Last Update Submitted: 2006-10-11
• Last Update Posted: 2006-10-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age > 18 years

• Positive agreement

• EPS for primary and secondary prophylaxis of a malignant ventricular tachyarrhythmia:

  • primary prophylaxis: Brugada syndrome, long QT syndrome, cardiomyopathy, short QT syndrome
  • secondary prophylaxis: Multicenter Automatic Defibrillator Implantation Trial (MADIT) criteria, syncope, documented ventricular tachycardia

Exclusion Criteria

• Severe neurological deficit
• Cardiopulmonary resuscitation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Trial Locations

Locations (1)

Fakultät für Klinische Medizin Mannheim Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg; 🇩🇪 Mannheim, Germany