Comparison of Intrathecal Dexmedetomidine Versus Fentanyl as Adjuvants to Bupivacaine on Post-operative Urinary Retention in Knee Joint Arthroscopic Surgeries
Overview
- Phase
- Phase 4
- Intervention
- hyperbaric bupivacaine and dexmedetomidine
- Conditions
- Post-Op Complication
- Sponsor
- Ain Shams University
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Post-operative urinary retention
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of this study was to assess the effect of intrathecally injected 5 µg dexmedetomidine or 25 µg fentanyl as adjuvants to bupivacaine in low dose spinal anesthesia for unilateral arthroscopic knee surgeries, on post-operative urinary retention (POUR), time needed to reach sensory block at the tenth thoracic dermatome (T10), the maximum sensory level achieved, the onset of motor block, the intra-operative fluids given, the duration of sensory and motor blocks, time to micturition or insertion of an intermittent urinary catheter and the number of patients who needed an indwelling (Foley's) catheter. Seventy patients, ASA physical status I or II, from 21 to 50 years old, scheduled to undergo unilateral arthroscopic knee surgeries under spinal anesthesia, were randomly divided into two equal groups; the Bupivacaine- Dexmedetomidine group (BD) patients and the Bupivacaine-Fentanyl group (BF) patients.
Investigators
Ghada M.Samir
Assistant Professor of Anesthesia
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •ASA physical status I and II
- •aged 21-50 years
- •scheduled to undergo unilateral arthroscopic knee surgeries under spinal anesthesia
Exclusion Criteria
- •Patients' refusal
- •contraindications to spinal anesthesia
- •patients with coagulopathy
- •infection at the lumbar region
- •pre-existing neurological deficits in the lower limbs
- •known allergy to any of the study drugs
- •urinary incontinence
- •cysto-ureteric reflux
- •patients with congestive heart failure
- •patients with dysrhythmia
Arms & Interventions
Bupivacaine-Dexmedetomidine group
Intervention: hyperbaric bupivacaine and dexmedetomidine
Bupivacaine-Fentanyl group
Intervention: Bupivacaine-Fentanyl group
Outcomes
Primary Outcomes
Post-operative urinary retention
Time Frame: 3 hours
Ultrasound assessment of the urinary bladder volume was done at the 3rd post-operative hour, a bladder volume of \>700 ml with no ability to void confirmed the presence of urinary retention
Secondary Outcomes
- Time to micturition or insertion of an intermittent urinary catheter(6 hours)
- Maximum sensory level achieved(30 minutes)
- Number of patients who needed an indwelling (Foley's) catheter(6 hours)
- Time to reach sensory block at T10(30 minutes)
- Duration of sensory block(6 hours)
- The onset of motor block(30 minutes)
- Intra-operative fluids given(3 hours)
- Duration of motor block(6 hours)