The Effect of Intrathecal Versus Intravenous Dexmeditomedine on Postoperative Analgesia in Transurethral Resection of the Prostate
Overview
- Phase
- Phase 4
- Intervention
- control group
- Conditions
- Dexmedetomidine
- Sponsor
- Tanta University
- Enrollment
- 75
- Primary Endpoint
- The time to first rescue analgesic
- Last Updated
- 5 years ago
Overview
Brief Summary
This study is to evaluate The analgesic effect of intrathecal versus intravenous dexmeditomedine in transurethral resection of the prostate
Detailed Description
This study will carried out in Tanta University hospital on75 male patients Patients will randomly classified into 3 groups Group I: will receive intrathecal hyperbaric bupivacaine 10mg in 2.5 ml and .5 ml saline with 3ml total volume Group II: will receive dexmeditomedine 5Mic diluted in.5 ml saline and hyperbaric bupivacaine 10mg in 2.5ml with 3ml total volume Group IIl: Will receive intravenous dexmeditomedine started at loading dose of 1 mic/kg diluted in 50 ml saline and administered within 10 min as loading dose , followed by maintenance at a dose of .4mic/kg/h diluted in200 ml saline till the end of surgery and hyperbaric bupivacaine 10 mg in 2.5 ml total volume
Investigators
Laila Elahwal
Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine
Tanta University
Eligibility Criteria
Inclusion Criteria
- •male gender
- •50:70years old
Exclusion Criteria
- •contraindications of spinal anesthesia
- •Patient refusal
- •Patient taking alpha agonist or antagonist
- •Uncontrolled cardiac diseases
- •Allergy to local anesthetic drugs
Arms & Interventions
Control (Placebo) group
Each patient will receive intrathecal hyperbaric bupivacaine 10 mg in 2.5 ml and 0.5 ml saline with 3 mL total volume. Continous 50 ml saline infusion for 10 min followed by 200 ml saline infusion till the end of surgery.
Intervention: control group
Intrathecal dexmedetomidine group
Each patient will receive dexmedetomidine 5 μg diluted in 0.5ml saline and hyperbaric Bupivacaine 10 mg in 2.5 ml with 3 mL total volume. Continous 50 ml saline infusion for 10 min followed by 200 ml saline infusion till the end of surgery.
Intervention: Intrathecal dexmedetomidine
Intravenous dexmedetomidine group
Each patient will receive intravenous dexmedetomidine started at a loading dose of 1 μg/kg diluted in 50 ml saline and administered within 10 min as a loading dose, followed by maintenance at a dose of 0.4 μg/kg/h diluted in 200 ml saline till the end of surgery and hyperbaric Bupivacaine 10 mg in 2.5 ml total volume.
Intervention: Intravenous dexmedetomidine
Outcomes
Primary Outcomes
The time to first rescue analgesic
Time Frame: 24 hours postoperative
The duration between the administration of spinal block and the first desire for supplemental analgesia (onset of 1st post-operative analgesic dose). First post-operative analgesic dose will be1 μg/kg intravenous fentanyl when visual analogue pain score (VAS) is 4 or more
Secondary Outcomes
- Intraoperative and postoperative complications(Intraoperative and 24 hours postoperative)
- Postoperative pain score Total dose of analgesic consumption I the first postoperative day Intraoperative and postoperative complications(24 hours postoperative)
- Total analgesic consumption(24 hours postoperative)