The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery : a Randomized, Double-blind, Controlled, Multicenter Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 468
- 试验地点
- 1
- 主要终点
- Incidence and duration of hypotension during anesthesia
研究概览
简要总结
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol in total intravenous anesthesia during abdominal surgery.
详细描述
Total intravenous anesthesia (TIVA) is one of the common anesthesia maintenance methods in clinic. Intravenous anesthetics commonly used in clinical practice include propofol and etomidate, both of which have their own advantages and disadvantages. Among them, propofol has the advantages of rapid onset, complete sedation and rapid recovery, but it is easy to cause injection pain. Moreover, the inhibitory effect of propofol on the circulatory system is more obvious, and the incidence of hypotension during propofol use in TIVA is higher. In contrast, intraoperative hypotension substantially increases the risk of perioperative adverse cardiovascular and cerebrovascular events. Etomidate, a derivative of imidazole, reversibly increases GABAA receptor activity and inhibits synaptic transmission and impulse transmission, resulting in sedation. Etomidate has a rapid onset of action, minimal hemodynamic effects, and a shorter dose-related half-life than propofol; however, etomidate has a suppressive effect on the adrenal cortex. Several studies have confirmed transient suppression of adrenocortical function with a single injection or continuous pump of etomidate, with recovery of preoperative baseline adrenocortical function within 48 hours after surgery.
Combined drugs can reduce the adverse reactions caused by single drugs. Considering the complementary effects of propofol and etomidate in pharmacodynamic characteristics, the combination of propofol and etomidate is beneficial to maximize their respective advantages and reduce adverse reactions.
Intraoperative hypotension is a common complication during general anesthesia, and severe hypotension is closely related to perioperative cardiovascular complications and stroke ; therefore, avoiding perioperative hypotension is the basic premise to ensure patient safety. Abdominal surgery is a common type of general surgery, with a large number of operations and relatively uniform operation time, which is easy to collect cases. Therefore, this study aims to investigate the effect of propofol-etomidate mixture used in TIVA on the incidence of hypotension during anesthesia induction and maintenance in adult patients undergoing elective abdominal surgery, in order to provide an alternative, safe, reasonable and easy to promote medication regimen for total intravenous anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA Ⅰ~Ⅲ;
- •BMI was 18-28 kg/m2;
- •For elective abdominal surgery under intravenous general anesthesia;
- •The expected duration of anesthesia was 1 to 4 hours.
排除标准
- •Pregnant patients;
- •Septic shock and multiple organ failure diagnosed within 14 days;
- •Hyperkalemia (serum potassium >5.5mmol/L) within 48 hours;
- •Stroke or transient ischemic attack within 3 months;
- •Patients with unstable angina pectoris or myocardial infarction within 3 months; Arrhythmia requiring treatment was not treated or treatment did not meet expectations;
- •Patients with preoperative diagnosed diabetes mellitus and uncontrolled blood glucose; Diabetic complications were diagnosed before surgery, including diabetic ketoacidosis, hyperosmolar coma, diabetes-related infection, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.
- •Severe liver and renal dysfunction;
- •Liver surgery, renal surgery, adrenal surgery, day surgery;
- •Resting blood pressure ≥180/110 mmHg (2020 ISH hypertension guideline ≥ grade 3 hypertension); Or systolic blood pressure <90mmHg or mean blood pressure <65mmHg.
- •Taking corticosteroids or other immunosuppressants for more than 10 days within 6 months or having a history of adrenal cortex suppression or immune system diseases;
- •Patients who participated in other drug trials within 3 months;
- •Patients with disturbance of consciousness or other mental diseases;
- •Confirmed/suspected abuse or long-term use of narcotic sedatives and analgesics；
- •Patients with cancer who received neoadjuvant therapy or chemotherapy before surgery;
- •Allergic to the drug used in this trial and its components.
研究组 & 干预措施
EP group
Patients in this group will receive etomidate- propofol mixture during induction and maintenance.
干预措施: Etomidate - propofol mixture (Drug)
P group
Patients in this group will receive propofol during induction and maintenance.
干预措施: Propofol (Drug)
结局指标
主要结局
Incidence and duration of hypotension during anesthesia
时间窗: during anesthesia
Systolic blood pressure ≤90 mmHg, or \> 20% reduction from baseline, or mean arterial pressure \<65 mmHg, from the time when anesthesia induction began to the time before the patient complied with transfer out of PACU
次要结局
- Recovery time(during anesthesia)
- Success rate of sedation(during anesthesia)
- The type and dosage of vasoactive drugs used during operation(during anesthesia)
- The incidence of postoperative nausea and vomiting(72 hours after surgery)
研究者
Ailin Luo
Professor
Tongji Hospital