Characterization and quantification of pulmonary serotonin transporter (SERT) by means ofPositron Emission Tomography (PET)/ Computer-Tomography (PET/CT) in patients with pulmonary hypertension (PH)
- Conditions
- right ventricular loadI27J44Other pulmonary heart diseasesOther chronic obstructive pulmonary disease
- Registration Number
- DRKS00009681
- Lead Sponsor
- niversitätsklinikum Leipzig
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
All participants:
- Age between 18 and 70 years
- ?/?
subgroup 1 - patients with ideopathic pulmonary hypertension
- pulmonary artery catheterization within the last 6 months
- no specific medication within initial diagnosis
- no structural pulmonary disease
subgroup 2 -patients with severe pulmonary hypertension with COPD
- COPD GOLD III and IV, resp. group C and D without exacerbation
- pulmonary artery catheterization within the last 6 months
- no specific medication within initial diagnosis
subgroup 3 - patients with comparable COPD without pulmonary hypertension
- COPD GOLD III and IV, resp. group C and D without exacerbation
- echocardiographical exclusion of pulmonary hypertension
subgroup 4 - healthy controls:
- echocardiographical exclusion of pulmonary hypertension
- under SSRI medication
- acute exacerbation of COPD
- right ventricular decompensation
- judicially or official ordered custody
- pregnancy, breastfeeding
- legal incapacity
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Based on the PET data it follows the calculation of an activity quotient between tissue and plasma as a direct measure of the distribution volume of the radiotracer and therefore of the transporter availability in the separate individuals
- Secondary Outcome Measures
Name Time Method comparison of pulmonary SERT-availabilty between the individuals as well as subgroups