Renal protection during open heart surgery

Not Applicable

• Conditions: acute kidney injury; heart disease; cardiothoracic surgery; Renal and Urogenital - Kidney disease; Cardiovascular - Coronary heart disease; Surgery - Other surgery

• Registration Number: ACTRN12619000128190
• Lead Sponsor: Monash Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-01-29
• Study Completion: 2021-09-03
• Last Update Posted: 9 January 2023

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Key inclusion criteria: (1) Non-emergency cardiac surgery on CPB (coronary artery bypass graft and/or valve surgery) at Monash Health, (2) An expected duration of CPB of 90 minutes or more.

Exclusion Criteria

(1) An expected duration of CPB of less than 90 minutes, (2) An expected nadir core body temperature during CPB of <32 °C (rare for this type of surgery), (3) Pre-existing AKI as defined by the KDIGO criteria, (4) Severe chronic kidney disease (serum creatinine >265 µmol/L), (5) Need for haemodialysis, (6) Prior renal transplantation, (7) A pre-operative state that precludes informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified