A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 2
- 主要终点
- The primary outcome measures include serial measures of vital signs and scores on the Clinical Institute Withdrawal Assessment for Alcohol-Revised scale (CIWA-Ar), a widely used scale that monitors alcohol withdrawal symptoms.
研究概览
简要总结
The purpose of this study is to compare the efficacy of two commonly used medications in the treatment of alcohol withdrawal, diazepam and lorazepam.
详细描述
Despite the frequent use of benzodiazepines for the treatment of alcohol withdrawal, studies comparing the efficacy of long and short half-life benzodiazepines in the treatment of alcohol withdrawal have shown mixed results. Due to the conflicting nature of published reports, clinicians have no clear indication as to which type of agent is preferable. The purpose of this study is to compare the efficacy of two commonly accepted medications in the treatment of alcohol withdrawal, diazepam and lorazepam, which are long and short half-life benzodiazepines, respectively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of alcohol withdrawal
- •History of alcohol use within 24 hours
- •Ability to consent to participate in the study
排除标准
- •Unwillingness to participate in the study
- •Active abuse of other CNS depressants
- •Acute intoxication with a CNS activating agent
- •Severe hepatic dysfunction
- •Pregnancy
- •History of dementia
研究组 & 干预措施
2
干预措施: Diazepam (Drug)
1
干预措施: Lorazepam (Drug)
结局指标
主要结局
The primary outcome measures include serial measures of vital signs and scores on the Clinical Institute Withdrawal Assessment for Alcohol-Revised scale (CIWA-Ar), a widely used scale that monitors alcohol withdrawal symptoms.
时间窗: one to two weeks
次要结局
- Secondary outcome measures include total benzodiazepine use.(one to two weeks)