NCT00696033已完成不适用
Exploring the Effects of Diazepam and Lorazepam on the Neural Correlates of Perceptual Priming and Explicit Memory in Healthy Volunteers
University Hospital, Strasbourg, France2 个研究点 分布在 1 个国家目标入组 22 人开始时间: 2007年7月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI
研究概览
简要总结
Aims :
- exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI
- comparing lorazepam effects to diazepam (0.3 mg/kg)effects
- exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI
Hypothesis :
- both diazepam and lorazepam will impair explicit memory performance, but lorazepam only will impair perceptual priming
- lorazepam and diazepam will modify the normal correlates of information encoding within explicit memory
- lorazepam only will alter the neural correlates of perceptual priming
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects between 18 and 30 years
- •Students in medicine, dentistry or pharmacy
- •French as a mother language
- •Exclusion criteria:
- •Medical condition influencing brain function (neurological or psychiatric)
- •General anesthesia in the 3 last months
- •Drug addiction (DSM IV criteria)
- •Regular medical treatment (except contraceptive pill)
- •Significant impairment observed during a medical examination including ECG
- •Intake of any psychotropic drug that can have a effect during testing
- •IQ (Wechsler) < 100
- •FMRI contra-indication (implantable magnetic material, claustrophobia)
- •Known allergy to benzodiazepine or lactose
- •> 10 cigarettes/day
- •Pregnant or breast-feeding woman
- •No health insurance
- •Subjects who do not complete the entire study
排除标准
- 未提供
研究组 & 干预措施
1
Experimental
Oral Lorazepam
干预措施: Lorazepam (Drug)
2
Experimental
Oral Diazepam
干预措施: Diazepam (Drug)
3
Placebo Comparator
Oral placebo
干预措施: placebo (Drug)
结局指标
主要结局
Exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI
时间窗: After a single oral intake
次要结局
- Comparing lorazepam effects to diazepam (0.3 mg/kg)effects(After a single oral intake)
- Exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI(After single oral intake)
研究者
研究点 (2)
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