To compare blood parameters in type 2 diabetes mellitus patients with and without nerve disorders .

Not yet recruiting

Conditions: Type 2 diabetes mellitus with neurological complications,

Registration Number: CTRI/2023/09/057374

Lead Sponsor: Kashish chaudhary

Brief Summary: Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Several distinct types of DM are caused by a complex interaction of genetic and environmental factors. Depending on the etiology of DM, factors contributing to hyperglycemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production .

DM leads to various complications which can be divided into microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular (coronary artery disease, cerebrovascular disease, and peripheral arterial disease).

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of DM. Previous studies have shown that 26.4% of type 2 DM patients are complicated by painful DPN , while up to 50% of the DPN patients may be asymptomatic .

Diabetic peripheral neuropathy is defined as the presence of symptoms and/or signs of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes (3).

Chronic inflammatory process has been shown to play a central role in DPN . Neutrophil-to-lymphocyte ratio (NLR) is a novel and inexpensive marker to reflect many kinds of inflammatory states including diabetes and its microvascular complications.

Diagnosing DPN depends on clinical examination and Nerve Conduction Study (NCS) but only large myelinated nerve fibers injury can be detected by traditional electrophysiological methods. However, development of DPN involves different diameters of peripheral, sensory and motor nerve fibers which creates difficulties for early detection and diagnosis of DPN. Thus, searching for a reliable indicator for early diagnosis is very important.

Studies are lacking which can show consistent relation between NLR and DPN thus, through this study we aim to assess and compare the NLR in type 2 DM patients with and without DPN.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 150

Inclusion Criteria

Patients of type 2 diabetes mellitus of any gender with and without peripheral neuropathy.

Exclusion Criteria

TYPE 1 DIABETES MELLITUS DIABETIC KETOACIDOSIS , HYPEROSMOLAR NON-KETOTC COMA CORONARY ARTERY DISEASE , HEART FAILURE ACTIVE INFECTION OR INFECTION IN LAST ONE MONTH CANCER ACCUTE POISONING BLOOD DISORDERS THAT AFFECT NEUTROPHILS AND LYMPHOCYTES(eg MYELOPROLIFERATIVE DISORDERS AND LEUKEMIA) SMOKING , SIGNIFICANT ALCOHOL INTAKE(MORE THAN 30g PER DAY IN MALES AND MORE THAN 20g PER DAY IN FEMALES) MEDICATIONS THAT AFFECT NLR (STEROIDS AND IMMUNOSUPPRESSIVE DRUGS) HYPOTHYROIDISM CHRONIC KIDNEY DISEASE VITAMIN B12 DEFICIENCY PEOPLE LIVING WITH HIV-AIDS(PLHA) HISTORY OF AUTOIMMUNE DISORDERS HISTORY OF BLOOD TRANSFUSION DURING PAST 2 WEEKS PREGNANCY.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine neutrophil to lymphocyte ratio in type 2 diabetes mellitus patients with and without peripheral neuropathy	Baseline

Secondary Outcome Measures

Name	Time	Method
To compare the NLR in type 2 diabetes mellitus patients with & without peripheral neuropathy	Baseline

Trial Locations

Locations (1): Guru gobind singh medical college and hospital
🇮🇳
Faridkot, PUNJAB, India
Guru gobind singh medical college and hospital
🇮🇳Faridkot, PUNJAB, India
Kashish chaudhary
Principal investigator
8901003652
kashishchaudhary22@gmail.com