study the effectiveness of dexmedetomidine, a drug,given before start of surgery by anesthetist, in preventing increase in blood pressure and pulse rate which generally occurs at that time and can result in dangerous arrhythmias and heart attack
Phase 4
Completed
- Conditions
- Health Condition 1: null- surgery under general anesthesia
- Registration Number
- CTRI/2011/10/002046
- Lead Sponsor
- Swai Maan singh Medical College and Attached hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1.Patients with ASA grade 1 and 2
2.Patients of age group 18 to 55 years of either sex undergoing surgery under general anesthesia
3.Patients willing to give written and informed consent
Exclusion Criteria
1.Patients refusal
2.Major organ dysfunction
3.Patients on medications like hypnotics, narcotic analgesics, α2 agonists, calcium channel blockers, β blockers
4.Patients with anticipated difficult intubation
5.Patients intubated after more than 1 attempt or more than 20 seconds
6.Patients with impaired LFT/RFT
7.Patients with ASA grade 3, 4, 5
8.Deaf and dumb patients
9.Patients with respiratory and cardiac disease
10.Patients having known allergy to anesthetic agents used in study
11.Psychiatric patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change in systolic, diastolic and mean blood pressure, pulse rate, oxgen saturation compared to baseline at various points before and after intubation compared to baselineTimepoint: 5 , 10 ,13,14(just after intubation),15,18,20,25 min after start of drug infusioon and baseline parameters
- Secondary Outcome Measures
Name Time Method complications like bradycardia , hypotention etcTimepoint: intraoperative( time period may vary and immediate post operative till 10 min after extubation