Evaluation of drug Dexmedetomidine as part of anaesthetic regimen during conduct of brain tumor surgery.
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Cerebello-pontine angle tumour patients
- Registration Number
- CTRI/2017/01/007667
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
Patients undergoing Cerebello-pontine angle surgeries with cranial nerve monitoring.
Exclusion Criteria
1)Patients with evidence of sino-atrial nodal or atrio-ventricular nodal bradyarrhythmia on ECG, baseline heart rate < 50/min.
2)Patients with known history of hypertension and being treated with anti-hypertensive drugs.
3)Patients on tricyclic antidepressant, clonidine, monoamine oxidase-inhibitor therapy.
4)Patients with evidence of impaired hepatic/renal function according to past history or preoperative biochemistry parameters.
5)Need for intraoperative inotrope/vasopressor drug.
6)Allergy to egg/propofol
7)Absence of cranial nerve monitoring during surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantification of anaesthetic and analgesic sparing effect of dexmedetomidine.Timepoint: End of anaesthesia.
- Secondary Outcome Measures
Name Time Method 1)Recovery from anaesthesia based on time to opening eyes, time to following commands and time to extubation after anaesthetic withdrawal. <br/ ><br>2)Evaluate the effect propofol alone and propofol-dexmedetomidine combination on acid base status. <br/ ><br>3)Observe the incidence of adverse haemodynamic events. <br/ ><br>4)Observe the effect of these two anaesthetic techniques on postoperative sedation, nausea and vomiting, shivering and pain scores. <br/ ><br>Timepoint: End of anaesthesia.