Cranberry-lingonberry Juice Started During Acute Infection in Prevention of Urinary Tract Infections in Children
- Conditions
- Urinary Tract InfectionCystitisPyelonephritis
- Registration Number
- NCT01861353
- Lead Sponsor
- University of Oulu
- Brief Summary
Cranberry and cranberry-lingonberry juice prevented urinary tract infections in children and in adults in our earlier clinical trials. The preventive effect was, however, observed late in the follow-up and the next recurrence was not prevented in children. The investigators hypothesize that cranberry-lingonberry juice should be started already during the antimicrobial treatment of acute urinary tract infection in order to maximize the preventive efficacy of the juice. In addition, the investigators aim to find the explanation for the efficacy of cranberry-lingonberry juice by analyzing the concomitant changes in the chemical composition of urine and feces as well as the changes of gut microbiota.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 113
- Recent confirmed urinary tract infection, diagnosed in Oulu University Hospital or Oulu Health Care Center
- Age 1-16 years
- Continuous antimicrobial prophylaxis
- Age < 12 months or > 16 years
- Severe congenital kidney or other urinary tract anomaly in ultrasound
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change of the intestinal and urinary microbiome 3 months to 12 months
- Secondary Outcome Measures
Name Time Method Time to the first recurrence 6 months The occurrence of urinary tract infections (infection episodes/person years at risk) 12 months
Trial Locations
- Locations (1)
Department of Pediatrics, University of Oulu
🇫🇮Oulu, Finland
Department of Pediatrics, University of Oulu🇫🇮Oulu, Finland