Cranberry Juice and Urinary Tract Infections
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 319
- 试验地点
- 1
- 主要终点
- Culture
研究概览
简要总结
The purpose of this study is to determine whether daily consumption of cranberry juice lessens the symptoms and prevents the recurrence of urinary tract infections (UTIs). This study will also determine whether drinking cranberry juice for 6 months selects for less virulent bacteria in the rectal, vaginal, and urethral areas.
详细描述
Participants in this study will be randomly assigned to consume either 8 ounces of cranberry juice or placebo juice twice a day for 6 months. Participants will have follow-up visits at 3 and 6 months, and whenever they experience a symptomatic episode. Urine, vaginal and rectal specimens will be taken at each visit to test for the presence of bacteria that cause urinary tract infections. Participants will complete a questionnaire at study entry, Day 3, Weeks 1 and 2, and monthly thereafter or whenever there is a recurrence of symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Culture-confirmed urinary tract infection at study start
排除标准
- •Other chronic disease
- •Antibiotics within 48 hours prior to study start
- •Hospitalization for any reason within 2 weeks prior to study start
- •Stones in urinary tract
- •Plans to leave Ann Arbor within 6 months after study start
- •Allergy to cranberry or cranberry compounds
- •Pregnancy
研究组 & 干预措施
1
Cranberry juice
干预措施: Cranberry juice (Drug)
2
Placebo juice
干预措施: Placebo cranberry juice (Dietary Supplement)
结局指标
主要结局
Culture
时间窗: per visit
次要结局
未报告次要终点