The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation

Completed

• Conditions: Liver Transplant; Complications; HLA Antigens
• Interventions: Other: HLA antigen results

• Registration Number: NCT04885582
• Lead Sponsor: Inonu University

Brief Summary

Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates depending on the experience gained, the most common biliary complications did not improve at the desired level. For this reason, studies in this field are frequent today.

The structural complexities of HLA antigens have been the subject of investigation in recent years. With the development of DNA and RNA amplification methods; It is increasingly difficult for physicians to keep up with the increasing burden of knowledge regarding the genetic aspects of these antigens. Concrete benefits of this gene complex, which has been investigated in various fields and preserves its mystery, have not been determined in liver transplant patients. However, there are publications showing its connection with the bile epithelium in liver transplantation and its relationship with the disappearing bile duct syndrome. In this study, our aim is to explain whether the bile duct complications, which appear like a continuous wall and can lead to frightening pictures, are related to HLA tissue compatibility.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-10
• Primary Completion: 2019-05-10
• Study Completion: 2020-05-20
• Status Verified: 2021-05
• Study First Submitted: 2021-05-11
• Study First Submitted QC: 2021-05-11
• Last Update Submitted: 2021-05-11
• Study First Posted: 2021-05-13
• Last Update Posted: 2021-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• patients with liver transplantation and tested for HLA antigen (recipient - donor)

Exclusion Criteria

• patients who died early Patients whose HLA antigen is not checked

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients without biliary complications	HLA antigen results	patients without postoperative biliary fistula and biliary stenosis
Patients with biliary complications	HLA antigen results	patients with postoperative biliary fistula, biliary stenosis

Primary Outcome Measures

Name	Time	Method
Bliary complications	2 years	Biliary fistüla, biliary stenosis

Trial Locations

Locations (1)

Health science University - Kayseri State Hospital; 🇹🇷 Kocasinan, Kayseri, Turkey