Impact of the intraoperative hemodynamic management on ischemia-sensitive tissues

Not Applicable

• Conditions: 5-885 (OPS) Autologous breast reconstruction; C50; N17.9; Malignant neoplasm of breast; Acute renal failure, unspecified

• Registration Number: DRKS00017735
• Lead Sponsor: niversitätsklinikum Regensburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-07
• Study Completion: 2021-09-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

Patients undergoing uni- or bilateral, primary or secondary DIEP flap autologous breast reconstruction are considered eligible for inclusion.

Exclusion Criteria

Increased preoperative serum creatinine levels or known kidney injury, congestive heart failure

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Analysis of highly sensitive kidney-specific urine parameters (TIMP-2 and IGFBP-7) via ELISA. Urine samples are taken pre-, intra- and postoperatively.

Secondary Outcome Measures

Name	Time	Method
Blood tests (analysis of serum creatinine levels and blood urea nitrogen); urine output; DIEP flap perfusion; renal replacement therapy; hospitalization;