The Impact of Inflammation on Skeletal Muscle Maintenance in Hospitalized Patients
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- FSR in high vs. low inflammation group
研究概览
简要总结
The main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. We will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. We will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. The hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalised at the geriatric department at Bispebjerg Hospital with an expected admission time of minimum 7 days
- •Have Disease Related Malnutrition (DRM)
- •Able to carry out strength training
- •Able to understand the study information, as assessed by the research team
排除标准
- •Current use of anti-inflammatory medication
- •Liver failure
- •Short bowel syndrome
- •Chrohn's or colitis
- •Terminally ill
研究组 & 干预措施
Anti-inflammatory diet and supplements
A sub group of patients with high inflammation will be offered a diet where 50% of the regular hospital diet is switched for diet containing plant based food and nutrients found to lower inflammation
干预措施: Single leg training (Other)
结局指标
主要结局
FSR in high vs. low inflammation group
时间窗: 7 days (or until hospital discharge)
The primary outcome is the muscle protein fractional synthesis rate (FSR) in the high inflammation group vs. the low inflammation group
次要结局
- Change in muscle size between groups(7 days (or until hospital discharge))
- FSR in trained vs. non trained leg(7 days (or until hospital discharge))
- AA uptake following feeding(7 days (or until hospital discharge))
- Muscle size in trained vs. untrained leg(7 days (or until hospital discharge))
- Inflammation in regular vs. antiinflammatory diet(7 days (or until hospital discharge))
- Change in muscle strength between groups(7 days (or until discharge))
- Muscle strength in trained vs. untrained leg(7 days (or until hospital discharge))
研究者
Grith Højfeldt
Principle Investigator
Bispebjerg Hospital