1 day vs 3 days of terlipressin therapy in cirrhosis patients with variceal bleeding
- Conditions
- Health Condition 1: - Health Condition 2: K74- Fibrosis and cirrhosis of liver
- Registration Number
- CTRI/2019/10/021771
- Lead Sponsor
- Dr Shalimar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
1. (compensated or decompensated) with acute variceal bleeding
2.Willing to participate in the study
1.Variceal bleeding secondary to causes other than cirrhosis. eg, extrahepatic venous obstruction, hepatic venous outflow tract obstruction
2.Patients with malignancy/disseminated intravascular coagulation (DIC)/known coagulopathic disorder (hemophilia) apart from cirrhosis.
3.History of intake of platelets inhibitors (e.g., aspirin, clopidogrel) and drugs affecting coagulation cascade (e.g., vitamin K antagonists) within the past 7 days
4.Pregnant women
5.Patients with chronic renal failure
6.Patients with shock or requiring mechanical ventilation
7.Sepsis
8.Acute on chronic liver failure
9.Hepatorenal syndrome
10.Hepatic encephalopathy
11.Contraindication to endoscopy
12.Not willing to provide consent
13.Active angina, Recent Myocardial infarction or dynamic EKG changes
14.Failure to control variceal bleed on initial endoscopy
15.Isolated gastric variceal bleeding
16.Spontaneous bacterial peritonitis at presentation
17.Hepatocellular carcinoma or other liver metastatic malignancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Control of variceal bleeding at 24 hours and 5-days.Timepoint: 1.Control of variceal bleeding at 24 hours and 5-days.
- Secondary Outcome Measures
Name Time Method 1.Rebleeding and mortality at 6 weeks. <br/ ><br>2.Difference in hepatic venous pressure gradient between the 2-groups at 1, 2 and 3 days post endoscopic variceal band ligationTimepoint: 6 weeks