Post-traumatic dysfunction of the innate and adaptive immune system and its relationship with the development of infectious complications in severely injured patients (POSEIDON study)
Completed
- Conditions
- blood poisoningsepsis100040181004795410027665
- Registration Number
- NL-OMON53029
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1. Severely injured trauma patients based on the following criteria:
- Severe injury (e.g. AIS > 3) in at least 2 body regions
- Physiological disturbances on hospital admission based on:
* Heart rate > 100 beats/min, and/or
* Systolic blood pressure < 100 mmHg, and/or
* Base excess < -6 mmol/L, and/or
* pH < 7,20, and/or
* Hb < 5,5
2. Admission to the IMCU or ICU of the UMCU with an expected stay of at least
48 hours.
3. Age: 18 - 80 years
4. Informed consent (when proxy consent is obtained and the patient leaves the
IMCU/ICU in good mental health, personal informed consent is additionally
necessary)
Exclusion Criteria
- Immunosuppressive medication
- Known HIV positive status and related diseases
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The difference in (anti-bacterial) characteristics of circulating neutrophils<br /><br>between trauma patients who develop sepsis and non-septic patients.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- The difference in (anti-bacterial) characteristics of circulating neutrophils<br /><br>between trauma patients who develop infectious complications other than sepsis<br /><br>(e.g. pneumonia, meningitis, urinary tract infections, pericarditis, abdominal<br /><br>abscesses, wound infections and fracture related infections) and non-infectious<br /><br>patients.<br /><br>- The difference in (anti-bacterial) characteristics of circulating neutrophils<br /><br>between trauma patients who develop pro-inflammatory complications (e.g. SIRS)<br /><br>and patients who don't develop these complications.<br /><br>- The difference in (inducible) activation status of neutrophils between<br /><br>patients with and without infectious or inflammatory complications</p><br>