Changing the traumatized patient'memory with Prolonged Exposure Therapy

Not Applicable

• Conditions: F43.1; Post-traumatic stress condition

• Registration Number: RBR-6msdqt
• Lead Sponsor: Fundação de Amparo à Pesquisa do Estado de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-03-04
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Meet the DSM-IV criteria for PTSD according to the Structured Clinical Interview for DSM Axis I Disorders, Patient Edition (SCID-I/P); being able to report the traumatic event; have emotional reactivity to trauma recall, defined as a minimum score of 40 in the Visual Analogue Scales (VASs) after describing the traumatic event; have regular menstrual cycle (female patients who were then tested in the follicular phase, defined as the first half of their usual cycle) or were taking hormonal contraceptive.

Exclusion Criteria

Patients were excluded if they had any medical condition that could threaten their safety, such as heart or neurological conditions, or current suicide risk; fulfill criteria for bipolar, psychotic, or substance use disorders; were in use of medications known to affect memory reconsolidation or extinction, such as beta-adrenergic blockers, benzodiazepines and anticonvulsants; current pregnancy; and previous participation in another study that could affect the present one.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It was expected that the traumatic retrieval group would present greater diminishing in skin conductance responses, compared to the neutral retrieval group. <br>The hyphotesis was confirmed by a statiscal model of Multiple Linear Regression, indicating that the group significantly predicted the outcome: ? = -.31, b = .58, adjusted p-value = .024, CI 95% = -.60 – -.04.

Secondary Outcome Measures

Name	Time	Method
It was expected to observe larger decrease in subjective resposes [by the scores of the following instruments, adapted for state version: Visual Analogic Scale, Davidson Traumatic Scale, Impact of Event Scale, Hamilton Depressiom Scale, Profile of Moods Scale and State-Trait Inventory for Anxiety (state version] in the traumatical retrieal group, compared to the neutral retrieval group. This hyphotesis was not confirmed. It could not be observed any diference between the groups, that could be signaled as statistically significant (p > 0.05)