Search for Genetic Factors in Parkinson*s disease
- Conditions
- ParkinsonismParkinson's Disease1002929910028037
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 700
- The probands (index cases) must have a diagnosis of idiopathic Parkinson*s disease according to the established clinical criteria (familial or sporadic disease).
- The relatives of the probands are first-, second-, or third-degrees relatives of the probands; they might or might not have Parkinson*s disease.
- The unrelated controls, as well as their first degree relatives, must be free from clinical signs of Parkinson*s disease and dementia.
- All subjects (probands, relatives, controls) must be 18 years of age at recruitment.
- All subjects (probands, relatives, controls) might be male or female.
- All subjects (probands, relatives, controls) must have signed the informed consent (before entry into study). In case of a legally incapacited subject, for instance due to cognitive impairment, the legal representative will be approached to obtain informed consent.
- Subjects who are unable to speak and be interviewed in Dutch or English (to ensure validity of the interviews).
- Patients with secondary forms of parkinsonism (such as drug-induced, toxic, vascular, tumour)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Genetics variants causing or predisposing to Parkinson*s disease.<br /><br>- Characterisation of the clinical phenotype associated to specific genetic<br /><br>variants. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Frequency of known mutations in the subjects.</p><br>