Search for Genetic Factors in Parkinson's Disease - II

Conditions: Parkinson's Disease
10028037
Parkinsonism

Registration Number: NL-OMON51549

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 700

Inclusion Criteria

- The probands (index cases) must have a diagnosis of idiopathic Parkinson's
disease according to the established clinical criteria (familial or sporadic
disease).
- The relatives of the probands are first-, second-, or third-degrees relatives
of the probands; they might or might not have Parkinson's disease.
- Due to possible shared etio-pathogenetic pathways, relatives of PD probands
- The unrelated controls, as well as their first degree relatives, must be free
from clinical signs of Parkinson's disease and dementia.
-All subjects (probands, relatives, controls) must be 16 years of age at
recruitment.
-All subjects (probands, relatives, controls) might be male or female.
-All subjects (probands, relatives, controls) must have signed the informed
consent (before entry into study). In case of a legally incapacitated subject,
for instance due to cognitive impairment, the legal representative will be
approached to obtain informed consent.

Exclusion Criteria

- Subjects who are unable to speak and be interviewed in Dutch or English (to
ensure validity of the interviews).
- Patients with secondary forms of parkinsonism (such as drug-induced, toxic,
vascular, tumor)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Genetics variants causing or predisposing to Parkinson's disease.<br /><br>- Characterisation of the clinical phenotype associated to specific genetic<br /><br>variants.<br /><br>- Investigation of molecular mechanisms of PD in patients with specific genetic<br /><br>variants.</p><br>

Secondary Outcome Measures