The Effect of Roux-en-Y Gastric Bypass on Mitochondrial Function in Type 2 Diabetes

• Conditions: Type 2 Diabetes; Obesity

• Registration Number: NCT01468116
• Lead Sponsor: Hvidovre University Hospital

Brief Summary

Roux-en-Y gastric bypass (RYGB) surgery induces resolution of type 2 diabetes, often within days after surgery and before significant weight loss. The aim of this study is to investigate whether changes in mitochondrial function contributes to the early improvement of type 2 diabetes after RYGB.

Detailed Description

Mitochondrial dysfunction has been linked to development of insulin resistance in the muscle and hence to the pathogenesis of type 2 diabetes. Mitochondrial function can be studied non-invasively by 31 Phosphor Magnetic Resonance spectroscopy (31PMRS). In this study we will investigate changes in mitochondrial function using the combination of 31 PMRS and Near Infra-Red Spectroscopy (NIRS) after gastric bypass.

Study Timeline

• Study Start: 2011-03
• Status Verified: 2011-11
• Study First Submitted: 2011-11-07
• Study First Submitted QC: 2011-11-07
• Last Update Submitted: 2011-11-07
• Study First Posted: 2011-11-09
• Last Update Posted: 2011-11-09
• Primary Completion: 2013-06
• Study Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients eligible for gastric bypass surgery or cholecystectomy
• Verified type 2 diabetes or normal glucose tolerance by OGTT

Exclusion Criteria

• Patients unable to fit the dimensions of the MRI-scanner

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Hvidovre University Hospital; 🇩🇰 Copenhagen, Hvidovre, Denmark