The Relationship Between Neurological Blood-based Biomarkers and Mid-term Cognitive Disorders in Critically Ill Survivors.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Speed of information processing assessment
研究概览
简要总结
Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β protein, neuron specific enolase, total Tau protein and neurofilament light chain) and the occurrence of cognitive disorders during the three months following intensive care discharge.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Anticipated ICU stay of at least 7 days for sepsis, acute respiratory distress syndrome, severe burns
- •French speaking
排除标准
- •hearing loss or blindness
- •mental retardation
- •known cognitive disorders or dementia
- •ICU admission for neurological disease
结局指标
主要结局
Speed of information processing assessment
时间窗: 3 months after ICU discharge
Administration of the Ways IV test (a Z-score will be used to score this item)
Cognitive disorders assessment (global assessment)
时间窗: 3 months after ICU discharge
Administration of the MOCA questionnaire (Montreal Cognitive Assessment) : scoring from 0 to 30, the highest score meaning the better cognitive outcome)
Memory disorder assessment
时间窗: 3 months after ICU discharge
Administration of the Reading Span (working memory) test (a Z-score will be used to score this item)
Executive function assessment
时间窗: 3 months after ICU discharge
Administration of the Go/No-go test (a Z-score will be used to score this item)
Blood neurological biomarkers levels
时间窗: 3 months after ICU discharge
Measurement of blood levels of neurofilament light chain
次要结局
未报告次要终点