The Relationship Between Neurological Blood-based Biomarkers and Mid-term Cognitive Disorders in Critically Ill Survivors.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intensive Care Unit Syndrome
- Sponsor
- University of Liege
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Speed of information processing assessment
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β protein, neuron specific enolase, total Tau protein and neurofilament light chain) and the occurrence of cognitive disorders during the three months following intensive care discharge.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Anticipated ICU stay of at least 7 days for sepsis, acute respiratory distress syndrome, severe burns
- •French speaking
Exclusion Criteria
- •hearing loss or blindness
- •mental retardation
- •known cognitive disorders or dementia
- •ICU admission for neurological disease
Outcomes
Primary Outcomes
Speed of information processing assessment
Time Frame: 3 months after ICU discharge
Administration of the Ways IV test (a Z-score will be used to score this item)
Cognitive disorders assessment (global assessment)
Time Frame: 3 months after ICU discharge
Administration of the MOCA questionnaire (Montreal Cognitive Assessment) : scoring from 0 to 30, the highest score meaning the better cognitive outcome)
Memory disorder assessment
Time Frame: 3 months after ICU discharge
Administration of the Reading Span (working memory) test (a Z-score will be used to score this item)
Executive function assessment
Time Frame: 3 months after ICU discharge
Administration of the Go/No-go test (a Z-score will be used to score this item)
Blood neurological biomarkers levels
Time Frame: 3 months after ICU discharge
Measurement of blood levels of neurofilament light chain