sing tourniquet and IV tranexamic acid in unilateral Total Knee Arthroplasty (TKA) surgery
Phase 3
Recruiting
- Conditions
- Condition 1: Knee osteoarthritis. Condition 2: Unilateral total knee arthroplasty.Unilateral primary osteoarthritis of kneeM17.1
- Registration Number
- IRCT20221228056952N1
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 168
Inclusion Criteria
Patients who refer to Ghaem hospital knee orthopedic clinic
Indicated for unilateral total knee arthroplasty (TKA) surgery
Exclusion Criteria
allergy to TXA
Active thromboembolic disease
Seizure disorder
Prior cerebrovascular accident
Cardiac stents or a history of thromboembolic disease
Prior renal disorder (glomerular filtration rate < 30 ml/min/1.73m2)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood loss volume. Timepoint: After surgery. Method of measurement: Postoperatively, blood loss will be calculated on the basis of the validated Gross formula, which includes sex, height, and weight, as well as pre-operative and postoperative day 2 hematocrit values with correction for any volume of blood administered.;Surgeon satisfaction with visualization during the procedure. Timepoint: After surgery. Method of measurement: Using a 10-point visualization scale, with 0 categorized as ‘‘poor’’ and 10 categorized as ‘‘good.’’ This will be completed by the operative surgeon at the end of the case.;Clinical outcomes. Timepoint: 2 and 6 months follow-up after surgery. Method of measurement: Pain score using Visual analogue scale (VAS), a 10-point visualization scale. Knee functional questionnaires of Oxford Knee Score, and WOMAC.
- Secondary Outcome Measures
Name Time Method