Two Time a Week vs. Five Time a Week Blood Flow Restriction Training Program for the Lower Extremity.

Not Applicable

• Conditions: Blood Flow Restriction Training
• Interventions: Other: 2x a week BFR training group; Other: 5x a week BFR training group

• Registration Number: NCT05342909
• Lead Sponsor: George Fox University

Brief Summary

This study will randomize healthy adults who regularly perform resistance training exercises for the lower extremities (2x a week) to one of three groups: a blood flow restriction (BFR) exercise group that trains 2x a week, a BFR exercise group that trains 5x a week, and a control group that does not perform any additional BFR exercise. Those randomized to the BFR groups will perform the unilateral 90-0 knee extension exercise followed by the bilateral squat. Subjects will have the BFR applied to their dominant lower extremity and will perform 4 sets (30/15/15/15 reps) per exercise. Training will initial start at 30% of 1RM with training intensity increased by 5% every 2 weeks. The training program will last 8 weeks.

Pre- and posttests include ultrasound imaging of the dominant leg rectus femoris and strength testing via hand held dynamometry.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-09-01
• Status Verified: 2022-04
• Study First Submitted: 2022-04-18
• Study First Submitted QC: 2022-04-18
• Last Update Submitted: 2022-04-18
• Study First Posted: 2022-04-25
• Last Update Posted: 2022-04-25
• Primary Completion: 2022-06-30
• Study Completion: 2022-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

healthy adults 18 years of age who currently perform weight-lifting (i.e., resistance training) exercise 2x a week.

Exclusion Criteria

current musculoskeletal injury; surgery to the low back or lower extremities during the prior year; one or more contraindications to blood flow restriction training.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2x a week BFR training group	2x a week BFR training group	Subjects will perform 2 exercises (LAQ and squat) with BFR applied to dominant thigh twice a week (2x/wk). Exercises performed for 4 sets (30/15/15/15 reps) initially at 30% 1RM; with load increased by 5% every 2 weeks. Training program lasts for 8 weeks. They are also to continue with their regular independent exercise program.
5x a week BFR training group	5x a week BFR training group	Subjects will perform 2 exercises (LAQ and squat) with BFR applied to dominant thigh daily (5x/wk). Exercises performed for 4 sets (30/15/15/15 reps) initially at 30% 1RM; with load increased by 5% every 2 weeks. Training program lasts for 8 weeks. They are also to continue with their regular independent exercise program.

Primary Outcome Measures

Name	Time	Method
Cross-sectional area of the rectus femoris	8 weeks	Ultrasound imaging will measure the cross-sectional area of the rectus femoris
Muscular strength	8 weeks	Hand held dynamometry will be used to assess changes in strength (bilaterally) for the quadricep, hip extensors, and hip abductors.

Trial Locations

Locations (2)

George Fox University; 🇺🇸 Newberg, Oregon, United States

George Fox University School of Physical Therapy; 🇺🇸 Newberg, Oregon, United States