Comparison of Characteristics of Bronchoalveolar Lavage Dusting and of Specific Questionnary Data in Healthy Volunteers and Patients Suffering From Sarcoidosis

Not Applicable

Completed

• Conditions: Sarcoidosis
• Interventions: Other: Bronchoalveolar lavage

• Registration Number: NCT02863406
• Lead Sponsor: Centre Hospitalier Saint Joseph Saint Luc de Lyon

Brief Summary

Comparison of dusting rate of bronchoalveolar lavage in healthy volunteers and patients suffering from sarcoidosis.

Blind analysis of bronchoalveolar lavage with Optical Microscopy, Transmission Electron Microscopy and MicroAnalysis.

For patients, comparison of bronchoalveolar lavage, pathological examination of biopsies (Optical Microscopy, Transmission Electron Microscopy and MicroAnalysis) and specific Professional and environmental questionnary.

Healthy volunteers matched with patients regarding to age (every 10 years), sex and tobacco consumption (non-smoking, smoking less than 5 pack-year, smoking between 5 and 10 pack-year, smoking more than 10 pack-year)

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Primary Completion: 2015-07
• Study Completion: 2015-07
• Status Verified: 2016-07
• Study First Submitted: 2016-07-05
• Study First Submitted QC: 2016-08-10
• Last Update Submitted: 2016-08-10
• Study First Posted: 2016-08-11
• Last Update Posted: 2016-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Absence of respiratory and cardiac illness (healthy volunteers)
• Normal spirometry and chest x-ray (healthy volunteers)
• Absence of viral infection (B and C hepatitis, HIV) (healthy volunteers)
• Confirmation of sarcoidosis (endoscopic exam with bronchoalveolar lavage) (patients suffering from sarcoidosis)

Exclusion Criteria

• Pregnant women
• Lack of bronchoalveolar lavage (volume less than 20 ml)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy volunteers	Bronchoalveolar lavage	Bronchoalveolar lavage in healthy volunteers
Patients suffering from sarcoidosis	Bronchoalveolar lavage	Bronchoalveolar lavage in patients suffering from sarcoidosis

Primary Outcome Measures

Name	Time	Method
Significant difference between dusting rate of bronchoalveolar lavage in healthy volunteers and patients suffering from sarcoidosis (analysis by Optical Microscopy, Transmission Electron Microscopy and MicroAnalysis).	Procedure of bronchoalveolar lavage

Secondary Outcome Measures

Name	Time	Method
Correlation between mineral overload of bronchoalveolar lavage for patient suffering from sarcoidosis and pathological examination of biopsies (analysis by Optical Microscopy, Transmission Electron Microscopy and MicroAnalysis).	Through study completion, an average of 1 year
Interest of macrophagic dusting index	Through study completion, an average of 1 year
Correlation between mineral overload of bronchoalveolar lavage for patient suffering from sarcoidosis and data extracted from specific Professional and environmental questionnary	Through study completion, an average of 1 year