Effects of a Chatbot-Based Intervention on Behavioral Responsiveness and Neural Anticipation of Social and Monetary Incentives in Individuals With Anhedonia

Anhedonia represents a core characteristic of depression and is characterized by reduced experience of pleasure. It is closely related to decreased motivation, altered reward processing, changes in affective responsiveness, and alterations in intrinsic brain network function. Anhedonia is not specifically targeted by currently available pharmacological interventions. Initial evidence indicates that an increased willingness to change and implementation of change in daily life can alleviate anhedonia.

The present study aims to examine whether a Motivational Interviewing-based AI chatbot can lead to changes in social incentive processing in college students with elevated anhedonia and depressive symptoms. Social incentive processing is included because social approval, social feedback, and interpersonal reward are important sources of motivation in daily life and may be altered in individuals with elevated anhedonia. The Social Incentive Delay Task allows the study to examine behavioral and neural responses during the anticipation and receipt of social incentives. To this end, eligible participants with a total score of 22 or higher on the Snaith-Hamilton Pleasure Scale and a score of 14 or higher on the Beck Depression Inventory will undergo a randomized, between-subjects, active-control intervention study. Participants will be assigned to either a Motivational Interviewing-based chatbot group or an active control chatbot group for 1 week. Pre- and post-intervention assessments will include self-report questionnaires and the Social Incentive Delay Task during functional magnetic resonance imaging to examine psychological, behavioral, and neural effects of the intervention.