antiproteinuric and antiinflammatory effect of vitamin D comparing with direct renin inhibitor in DKD

Phase 4

Completed

• Conditions: Age > 18DKD with eGFR > 15 ml/min Optimal dose of ACEI or ARB ≥ 3 monthsStable BP control ( Δ SBP ≤ 10% )Stable renal function ( Δ eGFR ≤ 10% )Stable glycemic c; vitamin D , Direct renin inhibitor , diabetic kidney disease

• Registration Number: TCTR20120000008
• Lead Sponsor: avamindhradhiraj university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2012-02-20
• Study Start: 2012-06-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

Age > 18
DKD with eGFR > 15 ml/min
Optimal dose of ACEI or ARB ≥ 3 months
Stable BP control ( ΔSBP ≤ 10% )
Stable renal function ( ΔeGFR ≤ 10% )
Stable glycemic control ( ΔHbA1C ≤ 15% x 2 in past 3 months )

Exclusion Criteria

Poorly controlled HT ( BP ≥ 150/95 mmHg )
Poorly controlled DM ( HbA1C > 8.5 % )
Hyperkalemia > 5 mg/dl
Hyperphosphatemia > 6 mg/dl
Hypercalcemia > 10 mg/dl
Taking vitamin D or its analog

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
proteinuria and inflammatory marker reduction 0, 6 wk pair t-test

Secondary Outcome Measures

Name	Time	Method
change in pro-BNP and PTH 0,6 wk pair t-test