Effects of Eccentric and Concentric Cycling Exercise Regimens on Hemodynamic and Hemorheologic Properties in Sedentary Male
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Central and peripheral hemodynamics
研究概览
简要总结
The effects of an eccentric endurance training on central and peripheral hemodynamic adaptations and erythrocyte rheology during maximal exercise remained to be unexplored. The current study examined the contribution of rheological functions and/or hemodynamic adaptation to changes in oxygen consumption (VO2) following the matched-power output eccentric (ECT) or concentric cycling training (CCT).
Method: A total of 39 sedentary males were randomly assigned into either CCT (n=13) or ECT (n=13) for 30 min a day, 5 days a week for 6 weeks at 60% of maximal workload or to a CTL (control group, n = 13). A graded exercise test (GXT) was performed before and after the intervention. Central and microvascular adaptations were evaluated using thoracic impedance and near-infrared spectroscopy (NIRS), respectively. Rheological characteristics was determined by an ektacytometer.
详细描述
Endurance training is a well known strategy for improving fitness capacity. However, some populations are intolerance to complete the usual exercise training program, such as chronic heart or pulmonary disease or the elderly. Therefore, ECT is a candidate training strategy for those individuals.
Erythrocytes deformability is significantly related to the blood perfusion in microcirculation. The impaired erythrocyte-related rheology further lead to reduced aerobic capacity by our research team. Therefore, the lower energy consumed in ECT may avoid the oxidative stress. To now, less studies have demonstrated whether ECT influences peripheral hemodynamics by erythrocyte rheology and the blood flow from the central effect.
The investigators aimed to investigate the effects of CCT and ECT on oxygen consumption response explained by changes in local blood perfusion, blood cell rheology, or central function to attempt developing its application in rehabilitation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •in sedentary lifestyle, who were nonsmokers, nonusers of medications/vitamins, and free of any cardiopulmonary/hematological risks
排除标准
- •regular exercise habits (i.e., exercise frequency once per week, duration >20 min).
结局指标
主要结局
Central and peripheral hemodynamics
时间窗: 12 weeks
Evaluate cardiac and peripheral hemodynamic response to exercise by using noninvasive continuous cardiac output monitoring system and near-infrared spectroscopy (NIRS).
次要结局
- Erythrocyte rheological characteristics(12 weeks)
- Cardiopulmonary fitness(12 weeks)
研究者
Jong-Shyan Wang
Consultant
Chang Gung Memorial Hospital