Study of the Neural Basis of Analogical Reasoning

Not Applicable

Completed

• Conditions: Progressive Supranuclear Palsy; Healthy Subjects; Frontotemporal Dementia

• Registration Number: NCT02236832
• Lead Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Brief Summary

Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-08-28
• Study First Submitted QC: 2014-09-09
• Study First Posted: 2014-09-11
• Study Start: 2015-02
• Status Verified: 2017-03
• Primary Completion: 2021-02
• Study Completion: 2021-02
• Last Update Submitted: 2022-03-21
• Last Update Posted: 2022-04-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

Healthy subjects:

• subject affiliated to national health insurance
• informed consent signed
• normal neurological examination
• subject aged at least 20

Patients:

• FTD or PSP diagnostic criteria filled
• patient affiliated to national health insurance
• informed consent signed

Exclusion Criteria

• Severe psychiatric symptomatology and psychotropic drug use
• unability to understand or perform the cognitive tasks.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Performance in the implicat task	day of inclusion (one day)	Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60).; Participants will come only once during one day ot the research centre.
Performance in the Similitude task	from inclusion to 4 months after inclusion	Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40).; Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.

Secondary Outcome Measures

Name	Time	Method
recording of EEG	day of inclusion (one day)	EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials.; Participants will come only once during one day a the research centre.
Analysis of MRI	day of inclusion (one day)	T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls.; Participants will come only once during one day at the research centre

Trial Locations

Locations (1)

ICM (Institut du cerveau et de la Moelle épinière); 🇫🇷 Paris, France