To compare the effects of airway pressure release ventilation and pressure control ventilation modes of ventilation on patients admitted in ICU requiring ventilator support
Phase 4
Completed
- Conditions
- Health Condition 1: J962- Acute and chronic respiratory failure
- Registration Number
- CTRI/2021/05/033420
- Lead Sponsor
- Government Medical College and Hospital Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
1) Patient on invasive mechanical ventilation in ICU for less than 24 hours
2) Stable hemodynamic parameters(Mean Arterial Pressure between 70-100mmHg, Heart Rate between 60-100/minute, SPO2-90%)
3) Richmond Agitation Sedation Scale between 0 and -2
4)Age group 18-60 years
Exclusion Criteria
1)Refusal of informed consent
2)Pregnant women
3)Morbidly obese patients (BMI > 35)
4)Patients diagnosed with ARDS (mild, moderate or severe)
5)Patients with severe or chronic heart, lung, hepatic, renal disease or neuromuscular disorder
6)Patient on vasopressor, cardiac depressants or neuromuscular blockers
7)Patients with traumatic brain or chest injury
8)Patients with severe multiple organ dysfunction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ventilatory parameters(Peak airway pressure, Platue pressure, Mean airway pressure, Complaince, Static compliance, Airway resistance)Timepoint: T1- 60 minutes after keeping on SIMV-VC corresponding to time just before switching to study ventilator mode 1 as per allocation. <br/ ><br>T2- 60 minutes after keeping on ventilator mode 1 <br/ ><br>T3- 60 minutes after switching back on SIMV-VC corresponding to time just before switching to study ventilator mode 2. <br/ ><br>T4- 60 minutes after keeping on ventilator mode 2
- Secondary Outcome Measures
Name Time Method 1)Haemodynamic parameters-Systolic blood pressure,Diastolic blood pressure,Mean arterial blood pressure,Heart rate,End -tidal cardon dioxide,Arterial oxygen saturation. <br/ ><br>2)Arterial blood gas analysis parameters- pH, Partial pressure of oxygen, Partial pressure of carbon dioxide, Arterial oxygen saturation.Timepoint: T1-60 minutes after keeping on SIMV-VC corresponding to time just before switching to study ventilator mode 1(as per group allocation) <br/ ><br>T2- 60 minutes after keeping on ventilator mode 1 <br/ ><br>T3- 60 minutes after switching back on SIMV-VC corresponding to time just before switching to study ventilator mode 2 <br/ ><br>T4- 60 minutes after keeping on ventilator mode 2