Implementation of a Non-invasive Version of the Imaging β-adrenergic-dependent Sweat Secretion Test

Not Applicable

• Conditions: Mucoviscidosis Involving the Lung

• Registration Number: NCT03584841
• Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Brief Summary

The goal of this study is to implement a non-invasive version of the sweat secretion test based in visualization of sweat glands following β-adrenergic stimulation of sweat. Specifically, the trial will evaluate the relative response of sweat glands to β-adrenergic and cholinergic stimulation among participants with CF, heterozygous and matched control subjects

Detailed Description

Not available

Study Timeline

• Study Start: 2017-03-31
• Study First Submitted: 2018-05-27
• Study First Submitted QC: 2018-07-11
• Study First Posted: 2018-07-12
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-23
• Last Update Posted: 2021-03-24
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• For patients with cystic fibrosis: clinically stable, all genotypes included.
• For healthy volunteer and heterozygous subjects: 18 years and older.

Exclusion Criteria

• Corticosteroids, anti-leukotriene therapy, unstable clinical status, <40% FEV1.
• Current pregnancy or breastfeeding.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Ratio between the β-adrenergic/cholinergic rate	up to 30 minutes	The ratio between the β-adrenergic/cholinergic rate (nL/min) of droplets of sweat is calculated.

Trial Locations

Locations (1)

Cliniques universitaires Saint-Luc; 🇧🇪 Brussel, Belgium