Comparison between Dexmedetomidine and Fentanyl for pain relief after abdominal surgeries.

Not Applicable

Completed

• Conditions: scheduled for hepaticojejunostomy

• Registration Number: CTRI/2014/08/004806
• Lead Sponsor: PostGraduate institute of medical education and research

Brief Summary

the purpose of the study was to compare and quantify the analgesic efficacy of dexmedetomoidine and fentanyl when both were used as an adjunct to thoracic epidural in patients undergoing hepaticojejunostomy under general anaesthesia. the addition of dexmededtomidine to 0.125% bupivacaine intraoperatively and postoperatively significantly reduces the requirement of bupivacaine as compared to fentanyl with comparable hemodynamic stability. the total consumption of rescue analgesia was significantly lower in dexmedetomidine group as compared to fentanyl group. the postoperative pain scores were comparable throughout the study between two groups and patients in dexmedetomidine group were more sedated.The heart rate was significantly lower in dexmedetomidine group as compared to fentanyl though the other haemodynamic parameters were comparable throughout the study.two patients in fentanyl group developed PONV whereas 2 patients in dexmed group developed mild nausea.no other side effects were reported in either of the two groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02-05
• Last Update Posted: 2014-07-31

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

ASA Class I and II, undergoing elective hepaticojejunostomy.

Exclusion Criteria

•BMI>35 kg/sq metre •Renal or hepatic dysfunction •Known cardiovascular disorder •Patients on beta-blockers, on long term treatment of antipsychotic drugs •Known allergy or senstivity to dexmedetomidine, bupivacaine or fentanyl •Contraindication to insertion of epidural catheter (local infection, spine deformities etc.) •Alcohol abuse, heavy smoking •Inability to use PCEA device.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
postoperative pain and analgesic requirements	24 hours postoperatively

Secondary Outcome Measures

Name	Time	Method
intraoperative analgesia and hemodynamic parameters	assessed every 5 min after start of epidural infusion for 30 min ,every 15 min till end of surgery.

Trial Locations

Locations (1)

department of anaesthesia; 🇮🇳 Chandigarh, CHANDIGARH, India

department of anaesthesia

🇮🇳Chandigarh, CHANDIGARH, India

Dr Shweta N Pokale

Principal investigator

9814012468

snp1986@gmail.com