on-invasive assessment of lung remodelling in patients with pulmonary arterial hypertension (PAH) using [18F]-FLT PET imaging.

Completed

• Conditions: pulmonary arterial hypetrension; 10037454

• Registration Number: NL-OMON47690
• Lead Sponsor: Vrije Universiteit

Brief Summary

Trial ended prematurely

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2020-01-09
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 36

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:
1.Diagnosis of PAH, according to ESC/ERS guidelines (ref: Galie ERJ 2015)
or
Unaffected BMPR2 mutation carrier
or
Normal control subjects
2. Age >50 and <80 years

Exclusion Criteria

- Pregnant subjects
- Claustrophobia
- Inability to provide informed consent
- In case of PAH patients: TLC < 70%pred or radiographic evidence of interstitial lung disease
- In case of BMPR2 mutation carriers and normal control subjects, one or more of the following: abnormal spirometry, TLC < 70%, echocardiographic evidence of pulmonary hypertension

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Uptake of [18F]-FLT in the lung of PAH patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>