Effects of Different Exercising Intensities and Frequencies of Walking Exercise on Depressive Mood and Insomnia in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Level of depression
研究概览
简要总结
Aerobic exercise intervention for depression was conventionally recommended three times weekly with moderate intensity in previous studies, but little is known about the training effect of aerobic exercise at low frequency and vigorous intensity. The purpose of this study is to compare the training effect of aerobic exercise at different exercising frequencies and intensities on older adults with comorbid insomnia and depressive symptoms. In this study, the investigators will investigate two types of aerobic exercise (i.e., vigorous-intensity exercise and moderate-intensity exercise) under different exercising frequencies (i.e., regular exercising pattern and weekend warrior). Individuals with chronic insomnia and depressive symptoms will be recruited and randomly allocated into 5 groups: 1) attention control group (stretching exercise), 2) moderate intensity exercise performed thrice weekly (MIE×3/wk), 3) moderate intensity exercise performed once weekly (MIE×1/wk), 4) vigorous intensity exercise performed thrice weekly (VIE×3/wk), and 5) vigorous intensity exercise performed once weekly (VIE×1/wk). Intervention will be maintained for 12 weeks. Outcome assessments will be conducted at baseline, 6 weeks and 12 weeks after the intervention. Outcomes including depressive status, chronic insomnia, objective sleep quality and pattern (measured by Actigraphy), subjective sleep quality (measured by Epworth sleepiness scale, insomnia severity index, PSQI), anxiety status (measured by HADS and GAD-7), quality of life (measured by SF-12), attention level (measured by computer attention test), exercise enjoyment (measured by physical activity enjoyment scale), habitual physical activity level (measured by IPAQ), aerobic fitness (measured by metabolic cart), body adiposity (measured by DXA), blood chemistry, adherence, medication usage, and adverse events will be measure in this study. This proposed study will provide pilot evidence for the benefits, effectiveness, safety, adherence, and sustainability of low-frequency vigorous aerobic exercise. the investigators expect the low-frequency exercise modality will enhance the practical suitability of aerobic exercise and will provide evidence for weekend warrior aerobic training strategy as a new exercise option in the management of elderly insomnia and depression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
Single-blind (Outcome Assessor)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •borderline abnormal depression with score above 8 out of 21 on Hospital Anxiety and Depression Scale (HADS),
- •chronic insomnia according to the fifth edition of the diagnostic and statistical manual of mental disorder (DSM-5),
- •Cantonese, Mandarin or English speaking, and 4) age 50 or above. To enhance generalizability, males and females will be recruited.
排除标准
- •contraindications to participating in physical exercise;
- •regular exercise habit in the past three months (i.e.,>75 minutes of vigorous-intensity exercise weekly or >150 minutes of moderate-intensity exercise weekly);
- •any pre-existing medical or physical issues that affect the experimental test and exercise intervention;
- •diagnosis with psychosis, schizophrenia or bipolar disorder;
- •currently receiving non-medication treatment for depression or insomnia, such as mindfulness training or cognitive behavior therapy;
- •shift worker or other commitment that interferes with the regular sleep pattern at night; and
- •abnormal heart's electrical activity according to the exercise electrocardiography (ECG) test, such as irregular heartbeat, arrhythmia, and myocardial infarction.
研究组 & 干预措施
Attention control
Subjects in this group will receive one session of 75 minutes stretching exercise per week throughout the 12 weeks experimental period
干预措施: Exercise intervention (Behavioral)
Moderate-intensity walking exercise ×3/wk
Subjects in this group will receive three sessions of 50 minutes vigorous walking exercise per week throughout the 12 weeks experimental period
干预措施: Exercise intervention (Behavioral)
Moderate-intensity walking exercise ×1/wk
Subjects in this group will receive one session of 150 minutes vigorous walking exercise per week throughout the 12 weeks experimental period
干预措施: Exercise intervention (Behavioral)
Vigorous-intensity walking exercise ×3/wk
Subjects in this group will receive three sessions of 25 minutes vigorous walking exercise per week throughout the 12 weeks experimental period
干预措施: Exercise intervention (Behavioral)
Vigorous-intensity walking exercise ×1/wk
Subjects in this group will receive one session of 75 minutes vigorous walking exercise per week throughout the 12 weeks experimental period
干预措施: Exercise intervention (Behavioral)
结局指标
主要结局
Level of depression
时间窗: After completion of the 12 weeks intervention
Hospital Anxiety and Depression Scale (HADS) will be used to measure the level of depression
Remission rate of insomnia
时间窗: After completion of the 12 weeks intervention
Brief insomnia questionnaire (BIQ) will be employed to diagnose the chronic insomnia based on the DSM-5 criteria.
次要结局
- Maximal oxygen consumption(After completion of the 12 weeks intervention)
- Objective sleep data(After completion of the 12 weeks intervention)
- Severity of depression(After completion of the 12 weeks intervention)
- Subjectively measured quality of life(After completion of the 12 weeks intervention)
- Habitual physical activity(After completion of the 12 weeks intervention)
- Subjective sleep data(After completion of the 12 weeks intervention)
- Body composition(After completion of the 12 weeks intervention)
- Blood chemistry tests(After completion of the 12 weeks intervention)
- Enjoyment of exercise intervention(After completion of the 12 weeks intervention)
- Attention level(After completion of the 12 weeks intervention)
- Change in dose of Sleep Medication(After completion of the 12 weeks intervention)
- Treatment response rate(After completion of the 12 weeks intervention)
- Anxiety level(After completion of the 12 weeks intervention)
- 7-day Sleep Diary(After completion of the 12 weeks intervention)