Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University of Illinois at Chicago
- Enrollment
- 146
- Locations
- 1
- Primary Endpoint
- Change in Depression Severity (observer-rated)
- Status
- Recruiting
- Last Updated
- 10 months ago
Overview
Brief Summary
The purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 years of age. The investigators will enroll a total of 146 participants.
This is a Phase-II trial that compares the efficacy of an exercise training program (POWER-MS) compared with a stretching program (FLEX-MS) for immediate and sustained reductions in the severity of depression among persons with MS who have MDD.
Investigators
Robert W Motl
Professor
University of Illinois at Chicago
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change in Depression Severity (observer-rated)
Time Frame: baseline (week 0), immediate follow-up (week 16 or 4 months), and long-term follow-up (week 32 or 8 months)
Hamilton Depression Rating Scale (HDRS-17); scores range between 0 (min) and 21 (max), higher scores reflect greater frequency of depressive symptoms.
Change in Depression Severity (self-report)
Time Frame: baseline (week 0), immediate follow-up (week 16 or 4 months), and long-term follow-up (week 32 or 8 months)
Patient Health Questionnaire (PHQ-9); scores range between 0 (min) and 27 (max), higher scores indicate greater depression severity.
Secondary Outcomes
- Change in Quality of Life(baseline (week 0), immediate follow-up (week 16 or 4 months), and long-term follow-up (week 32 or 8 months))
- Change in Perception of Fatigue Severity(baseline (week 0), immediate follow-up (week 16 or 4 months), and long-term follow-up (week 32 or 8 months))
- Change in Cognitive Performance(baseline (week 0), immediate follow-up (week 16 or 4 months), and long-term follow-up (week 32 or 8 months))