Exercise and Severe Depression: Clinical and Biological Analysis

Hospital de Clinicas de Porto Alegre1 site in 1 country50 target enrollmentJanuary 2008

Overview

The study aimed to evaluate the use of exercise as a complementary strategy to treat severe major depression in inpatients.

Hypothesis: Exercise can be used as a safe and efficacious complimentary strategy in severe depressed inpatients.

Registry

clinicaltrials.gov

Start Date

January 2008

End Date

December 2012

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Sponsor

Responsible Party

Sponsor

•Diagnosis of Major Depressive Disorder according to M.I.N.I (DSM-IV) criteria American Psychiatry Association(1994)
•score of 25 or more on Hamilton-17
•not being involved in other physical activity programs during the hospitalization
•aged between 18 and 60 years
•being able to read, understand, and provide written informed consent

•have three or more cardiovascular risk factors according to Physical Activity Readiness Questionnaire (PAR-Q)
•are unable to exercise due other clinical condition
•have diagnosis of Schizophrenia, Bipolar disorder or current use of alcohol or other drugs according to M.I.N.I DSM-IV criteria American Psychiatry Association(1994)
•if they are taking beta-blocking medications

Depressive symptoms

Time Frame: 2 weeks of hospitalization (14 days)

Hamilton 17 for depression

Brain-Derived Neurotrophic Factor(BDNF)(Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks))
Thiobarbituric acid reactive substances(TBARS)(Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks))
Quality of Life(Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks))
Depressive symptoms at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks)(Discharge)