Single dose ketamine pharmacokinetic-pharmacodynamic relationships in healthy volunteers

Phase 1

Withdrawn

• Conditions: major depressive disorder; post traumatic stress disorder; obsessive compulsive disorder; generalized anxiety disorder; social phobia; Mental Health - Depression; Mental Health - Anxiety

• Registration Number: ACTRN12616001592437
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-11-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Capable of understanding and signing an informed consent
Aged > 18 years on the day of consent
Good general health
Suitable venous access

Exclusion Criteria

1.Females who are or intend to become pregnant, or are lactating.
2.Participants who, in the opinion of the investigator, do not understand the information and procedures of the study, or would not be compliant with them (in particular the study restrictions and risks involved).
3.Any participant for whom the investigator believes, for any reason, that participation would not be an acceptable risk.
4.Current use of monoamine oxidase inhibitors (MAOIs), thyroxine or stimulants (amphetamine/methyphenidate)
5.Regular use of any drug that alters mood or is used to treat mental disorder, including daily use of alcohol or use of alcohol within 24 hours of testing.
6.Use of medications that may alter BDNF concentrations, including antidepressants
7.Subjects with a prior history of seizures; susceptibility to photosensitivity; or a history of allergic skin reactions.

Study & Design

• Study Type: Interventional
• Study Design: Not specified