Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema

Recruiting

• Conditions: Lymphedema
• Interventions: Other: Patients underwent lymphedema surgery; Other: Patients underwent surgery without LVA

• Registration Number: NCT06237907
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

The project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Detailed Description

This project aims to investigate the expression of cell death through apoptosis and iron-dependent cell death in the subcutaneous adipose tissue of patients with lymphedema. The study also seeks to explore the roles of these processes among lymphatic endothelial cells, adipocytes, and macrophages, and their association with lymphedema, thus gaining insights into the pathophysiological mechanisms of lymphedema. Furthermore, the project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Study Timeline

• Status Verified: 2023-09
• Study Start: 2023-09-20
• Study First Submitted: 2024-01-16
• Study First Submitted QC: 2024-01-24
• Last Update Submitted: 2024-01-24
• Study First Posted: 2024-02-02
• Last Update Posted: 2024-02-02
• Primary Completion: 2024-09-20
• Study Completion: 2026-01-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Control Group: Patients who have not experienced lymphedema but require surgery due to other diseases such as cancer, trauma, chronic wounds, skin defects, etc.
• Experimental Group: Patients who have lymphedema and undergone lymphedema surgery.

Exclusion Criteria

• 1. Individuals with venous thrombosis, chronic heart failure, and renal failure.
• 2. Vulnerable populations, individuals with limited mobility, pregnant women, and minors.
• 3. Those expected to be unable to attend follow-up visits or complete the study smoothly.
• 4. Participants who express doubts about the trial and cannot provide satisfactory answers.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients underwent surgery	Patients underwent surgery without LVA	-
Patients underwent surgery	Patients underwent lymphedema surgery	-

Primary Outcome Measures

Name	Time	Method
The correlation between post-LVA volume reduction	1 month after surgery	The differences in expression of cell necrosis and iron-dependent cell death after lymphedema surgery were observed in patients, following alleviation of edema symptoms.

Trial Locations

Locations (1)

Kaohsiung Chang Gung Memorial Hospital; 🇨🇳 Kaohsiung, Taiwan