Evaluation of the effect of epidural anesthesia on aute lung injury induced by one lung ventilation in patients undergoing lobectomy for lung cancer
Not Applicable
- Conditions
- lung cancer
- Registration Number
- JPRN-UMIN000023139
- Lead Sponsor
- Keio University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
Heart disease with NYHA 2-4 PaO2 less than 60mmHg under room air FEV1.0% less than 50% Platelet count less than 100000/mm3 Coagulation disorder (PT-INR > 1.5)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The concentration of IL-6 in epithelial lining fluid (ELF) of respiratory tract mucosa
- Secondary Outcome Measures
Name Time Method The concentrations of other inflammatory cytokines (TNF-alpha, IL-1beta, IL-8, IL-10) in ELF, plasma cytokine (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10) and malondialdehyde concentrations, blood gas analysis, postoperative pulmonary complications and organ injuries, postoperative pain evaluated by numerical rating scale, and the length of hospital stay