Pharmacokinetic-pharmacodynamic modeling of S(+)-ketamine in healthy volunteers.
- Conditions
- Healthy volunteers free of pain will be tested.
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
1. Healthy volunteers 18+.
Exclusion Criteria
1. Obesity (BMI > 30);
2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurologic disease; diabetes m.; pyrosis; diaphragmatic hernia);
3. Presence of psychiatric disease;
4. History of chronic alcohol or drug use;
5. Allergy to study medications;
6. Possibility of pregnancy and
Lactation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Analgesia and Plasma Cp of ketamine.
- Secondary Outcome Measures
Name Time Method Bowdle scale parameters.