Complex Regional Pain syndrome: a (focal) small fibre neuropathy possibly related to mutations in voltage-gated sodium channels
Withdrawn
- Conditions
- painful neuropathyPeripheral neuropathy10034606
- Registration Number
- NL-OMON37879
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Inclusion criteria
- diagnosis CRPS1 according to IASP criteria
- age > 18 years
- at least 2 or more symptoms compatible with SFN
- normal findings at neurological and EMG examination, besides changes compatible with SFN involvement.
Exclusion Criteria
-
- symptoms and signs of large fibre involvement at neurological examination
- current or previous neurologic abnormalities unrelated to reflex sympathetic dystrophy
- presence of Raynaud*s disease
- another condition affecting the function of the disease or contra-lateral extremity
- abnormal EMG findings
- diagnosis CRPSII
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The presence of mutations in the SCN9A gene.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- The presence of mutations in SCN10A and SCN11A genes.<br /><br>- Genotype to phenotypical findings (at the impairment level like pain and<br /><br>fatigue severity, autonomic deficits, fatigue, and quality of life impact) of<br /><br>CRPS patients having SCN9A mutations versus those who remain with an unknown<br /><br>aetiology. </p><br>