Complex regional pain syndrome and primary headache: coincidence or causality? - From a neurophysiological point of view

Suspended

• Conditions: G90.7; G43; Complex regional pain syndrome, other and unspecified type; Migraine

• Registration Number: DRKS00026611
• Lead Sponsor: niversitätsklinikum Greifswald

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Suspended
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Arm 1:
- Diagnosis CRPS

Arm 2:
- Diagnosis: episodic migraine

Arm 3
- healthy controls

Exclusion Criteria

- mental illness (mild depression excluded)
- MRI contraindication (pacemaker, medication pumps, claustrophobia)
- CGRP antibodies for migraine prophylaxis
- Prophylactic Botox therapy (migraine prophylaxis)
- Epilepsy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Combined endpoint of R2 area and habituation of the nociceptive blink reflex.

Secondary Outcome Measures

Name	Time	Method
Medical history<br>- Demography and social anamnesis<br>- Medical history<br>- Medication history<br>- Family history<br><br>II) Electrophysiology<br>- Blink reflex<br>- Nociceptive evoked potentials<br>- Somatosensory evoked potentials (SSEP)<br>- Motor evoked potentials (MEP)<br> - conditioned with peripheral somatosensitive<br> Stimulation<br> - conditioned by activation<br>- Connectivity in the electroencephalogram (EEG)<br><br>III) Imaging<br>- structural MRI (volumetry, tractrography)