Patterns of recovery following sudden kidney failure
Not Applicable
- Conditions
- Health Condition 1: N170- Acute kidney failure with tubularnecrosis
- Registration Number
- CTRI/2019/08/020565
- Lead Sponsor
- Jawaharlal Institute of postgraduate Medical Education Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All dialysis requiring patients with AKI (defined as more than or equal to 1.5 times increase in the baseline creatinine within 7 days or more than or equal to 0.3mg/dl increase from the baseline creatinine within 48hours or urine output of less than 0.5ml/kg/hr for 6 hours )
Exclusion Criteria
1. CKD stage 5d (eGFR <15ml/min)
2. Obstructive uropathy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To assess the tubular recovery in patents with dialysis requiring AKI with urinary TIMP2(Tubular inhibitor of metalloproteinase 2) and IGFBP-7(Insulin like growth factor binding protein-7) as candidate markers <br/ ><br> 2. To assess the renal reserve in patients who show a complete recovery of AKI (eGFR60ml/min and uACR of 30 at 3 months after the onset of AKI) <br/ ><br>Timepoint: Outcomes will be assessed at 3 months from onset of Acute Kidney Injury
- Secondary Outcome Measures
Name Time Method To correlate the renal injury markers and renal reserve with eGFR at 1 year following AKITimepoint: One year