EUCTR2009-017356-28-GB
Active, not recruiting
Phase 1
Evaluation of Beta Blockers for the Treatment of Asthma. A randomised controlled trial of propranolol.
niversity of Dundee0 sites15 target enrollmentMarch 17, 2010
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- asthma
- Sponsor
- niversity of Dundee
- Enrollment
- 15
- Status
- Active, not recruiting
- Last Updated
- 9 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Male and female volunteers with stable mild intermittent or mild persistent asthma. Stable defined as: FEV1 \>80% predicted with diurnal FEV1 variation \<30% when LABA washed out. Methacholine PC20 \<4mg/ml.
- •Male and female participants, aged between 18 to 65\.
- •Ability to perform spirometry, IOS, bronchial challenge and all domiciliary measurements.
- •Ability to obtain Informed consent.
- •Mild to Moderate Asthmatics taking \=1000µg BDP per day or equivalent.
- •Withold LABAs for 1 week prior to study.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range
Exclusion Criteria
- •Uncontrolled symptoms of asthma.
- •Resting BP\<110 systolic or HR\<60\.
- •Pregnancy or lactation.
- •Known or suspected sensitivity to the IMP(s).
- •Inability to comply with protocol.
- •Any degree of heart block.
- •Rate limiting medication including ß blockers, rate limiting Calcium Channel Blockers and Amiodarone.
- •Any other clinically significant medical condition that may either endanger the health or safety of the participant, or jeopardise the protocol.
- •An asthma exacerbation within the last 6 months.
Outcomes
Primary Outcomes
Not specified
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