Evaluation of Beta Blockers for the Treatment of Asthma. A randomised controlled trial of propranolol.

niversity of Dundee0 个研究点目标入组 15 人开始时间: 2010年3月17日最近更新: 2017年4月3日

适应症

试验速览

暂无简介。

•Male and female volunteers with stable mild intermittent or mild persistent asthma. Stable defined as: FEV1 >80% predicted with diurnal FEV1 variation <30% when LABA washed out. Methacholine PC20 <4mg/ml.
•Male and female participants, aged between 18 to 65.
•Ability to perform spirometry, IOS, bronchial challenge and all domiciliary measurements.
•Ability to obtain Informed consent.
•Mild to Moderate Asthmatics taking =1000µg BDP per day or equivalent.
•Withold LABAs for 1 week prior to study.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Uncontrolled symptoms of asthma.
•Resting BP<110 systolic or HR<60.
•Pregnancy or lactation.
•Known or suspected sensitivity to the IMP(s).
•Inability to comply with protocol.
•Any degree of heart block.
•Rate limiting medication including ß blockers, rate limiting Calcium Channel Blockers and Amiodarone.
•Any other clinically significant medical condition that may either endanger the health or safety of the participant, or jeopardise the protocol.
•An asthma exacerbation within the last 6 months.

发起方

niversity of Dundee