IRCT20230301057584N1招募中3 期
Investigating the effectiveness of beta-blockers on hypermetabolic response in adult patients referred to hospital due to acute burns: a single-blind randomized clinical trial
Bandare-abbas University of Medical Sciences0 个研究点目标入组 90 人开始时间: 待定最近更新:
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 65 years（—）
- 性别
- All
入选标准
- •Having wounds from 20 to 50% of the total body surface
- •Consent to participate in data collection
- •From the age of 18 to the age of 65 and of both sexes
- •A history of acute burns in the last two days
排除标准
- •Medical conditions against propranolol use
- •Head injury
- •History of cardiopulmonary
- •endocrine and peripheral diseases
- •Systolic blood pressure less than 90
- •Heart rate less than 60
- •Inhalation damage
- •History of malignancy
- •History of AIDS
- •Complexes related to AIDS and HIV
- •History of IMI (less than the last 6 weeks), tuberculosis, arthritis, cirrhosis, hyperlipidemia, bone or endocrine diseases, autoimmune diseases
- •Long-term use of corticosteroids or non-steroidal anti-inflammatory drugs
- •Renal failure defined as creatinine greater than 3
- •Liver disease defined as bilirubin more than 3
- •Anoxic brain damage
- •Patients with asthma and a history of airway narrowing
- •Respiratory burn
- •History of joint or bone disease
- •Peripheral or central nerve damage
- •Diabetes or taking any medication that affects the autonomic system
- •Any type of plastering
- •Skin wound or skin graft
- •Contraindication to the use of propranolol
- •Hypersensitivity to propranolol
- •A history of hyperthyroidism, unless you are using Synthroid or other thyroid hormones
- •Chronic opioid overdose pre-burn
- •Receiving propranolol in the past 6 months
- •Multiple severe allergic reactions
- •Daily use of methylphenidate or similar stimulants
- •Presence of hypoxic brain injury that is not expected to lead to full recovery
- •History of chronic obstructive pulmonary disease and history of medication use including blocking agents (alpha and beta) or other antiarrhythmic drugs and medical conditions requiring glucocorticoid therapy prior to burn injury.
研究者
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